Functional diversity in the dynamin family

Trends Cell Biol. 1999 Mar;9(3):96-102. doi: 10.1016/s0962-8924(98)01490-1.


The function of the GTPase dynamin has been discussed for several years. It clearly plays a role in vesicle budding, but, despite recent insights, precisely how it functions in this process is still a matter of debate. In addition, it is now clear that dynamin is a member of a large protein family, present in a variety of cellular locations where members apparently perform a range of functions. This article describes current understanding of the structure and function of the various dynamin family members.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Dynamins
  • GTP Phosphohydrolases / classification
  • GTP Phosphohydrolases / metabolism
  • GTP Phosphohydrolases / physiology*
  • Humans
  • Molecular Sequence Data


  • GTP Phosphohydrolases
  • Dynamins