The role of COP1 in repression of Arabidopsis photomorphogenic development

Trends Cell Biol. 1999 Mar;9(3):113-8. doi: 10.1016/s0962-8924(99)01499-3.


Photomorphogenic development in Arabidopsis is regulated by the key repressor COP1, which interacts with specific transcription factors in the nucleus to modulate their activities. In the dark, COP1 accumulates in the nucleus and represses photomorphogenic development. Light diminishes the nuclear accumulation of COP1 and abrogates its repressor activity. A number of cellular components are involved in light-dependent nucleocytoplasmic partitioning of COP1, including the multisubunit COP9 complexes and at least three well-characterized photoreceptors. This review discusses current understanding of the mechanisms of COP1 action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arabidopsis / physiology
  • Arabidopsis Proteins*
  • Binding Sites
  • COP9 Signalosome Complex
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Cell Nucleus / metabolism
  • GTP-Binding Proteins*
  • Intracellular Signaling Peptides and Proteins
  • Light
  • Nuclear Proteins / metabolism
  • Photosynthetic Reaction Center Complex Proteins
  • Plant Proteins / metabolism
  • Plant Proteins / physiology*
  • Proteins / metabolism
  • Repressor Proteins*
  • Transcription Factors / metabolism
  • Ubiquitin-Protein Ligases*


  • Arabidopsis Proteins
  • CSN1 protein, Arabidopsis
  • Carrier Proteins
  • DET1 protein, Arabidopsis
  • GPS1 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • Photosynthetic Reaction Center Complex Proteins
  • Plant Proteins
  • Proteins
  • Repressor Proteins
  • Transcription Factors
  • AT2G32950 protein, Arabidopsis
  • Ubiquitin-Protein Ligases
  • COP9 Signalosome Complex
  • GTP-Binding Proteins