Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome

Ophthalmology. 1999 Apr;106(4):811-6. doi: 10.1016/S0161-6420(99)90171-9.


Objective: To review the efficacy and side effects of topical nonpreserved corticosteroid therapy for treatment of severe keratoconjunctivitis associated with Sjögren syndrome.

Design: Retrospective, noncomparative case series.

Participants: Twenty-one patients with Sjögren syndrome-associated keratoconjunctivitis sicca and annoying ocular irritation.

Intervention: Treatment with topical nonpreserved methylprednisolone sodium succinate.

Main outcome measures: Symptom severity, frequency of instillation of artificial tears, corneal fluorescein staining scores, resolution of filamentary keratitis, steroid-related side effects.

Results: Before starting methylprednisolone therapy, all patients were experiencing moderate-to-severe eye irritation despite prior punctal occlusion in most cases and frequent use of nonpreserved artificial tears by all. After 2 weeks of topical application, three to four times per day, moderate (43%) or complete (57%) relief of irritation symptoms was experienced by all patients and no complications were observed. An average decrease in corneal fluorescein scores of 2.6 +/- 0.5 points (on a 12-point scale) was observed, and filamentary keratitis resolved in all ten eyes with this condition. Therapy was stopped after 2 weeks in eight patients, and six of these patients reported that their symptoms remained at a tolerable level for weeks to months. Lower dose steroid therapy was continued in the remaining patients, whose symptoms worsened after attempted weaning. Complications of corticosteroid therapy in patients receiving prolonged therapy included increased intraocular pressure in one patient at 3 months, worsening of pre-existing posterior subcapsular cataracts in one patient at 6 months, and formation of posterior subcapsular cataracts in another patient at 6 months.

Conclusions: These findings indicate that topical nonpreserved methylprednisolone is an effective treatment option for patients suffering from severe keratoconjunctivitis sicca who continue to experience bothersome eye irritation despite maximum aqueous enhancement therapies. They also suggest that inflammation is a key pathogenic factor in this condition. Careful monitoring is essential in dry eye patients treated with corticosteroids for more than 2 weeks because steroid-related complications (increased intraocular pressure and cataract formation) were observed after several months of therapy in this series. Because of the chronic nature of this disease and the likelihood of patients developing steroid-related complications with their long-term use, topical nonpreserved methylprednisolone therapy appears to be most appropriate for short-term "pulse" treatment of exacerbations of keratoconjunctivitis sicca.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use*
  • Cornea / metabolism
  • Female
  • Fluorescein / metabolism
  • Fluorophotometry
  • Glucocorticoids
  • Humans
  • Keratoconjunctivitis Sicca / drug therapy*
  • Keratoconjunctivitis Sicca / etiology
  • Keratoconjunctivitis Sicca / metabolism
  • Male
  • Methylprednisolone Hemisuccinate / adverse effects
  • Methylprednisolone Hemisuccinate / therapeutic use*
  • Middle Aged
  • Preservatives, Pharmaceutical*
  • Retrospective Studies
  • Sjogren's Syndrome / complications*
  • Tears / metabolism
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Preservatives, Pharmaceutical
  • Methylprednisolone Hemisuccinate
  • Fluorescein