First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines

D H Kim; Y Jin

doi:10.1016/s0960-894x(99)00055-4

First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines

Bioorg Med Chem Lett. 1999 Mar 8;9(5):691-6. doi: 10.1016/s0960-894x(99)00055-4.

Authors

D H Kim¹, Y Jin

Affiliation

¹ Center for Biofunctional Molecules and Department of Chemistry, Pohang University of Science and Technology, Korea.

PMID: 10201830
DOI: 10.1016/s0960-894x(99)00055-4

Abstract

A series of N-acyl-N-hydroxy-beta-Phe were designed, synthesized, and shown to have potent inhibitory activity for carboxypeptidase A (CPA). They are the first examples of CPA inhibitors having a hydroxamate functionality.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Bacillus / enzymology
Carboxypeptidases / antagonists & inhibitors*
Carboxypeptidases / chemistry
Carboxypeptidases A
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Phenylalanine / chemical synthesis*
Phenylalanine / pharmacology
Protein Conformation
Structure-Activity Relationship
Thermolysin / antagonists & inhibitors
Thermolysin / chemistry
Thermolysin / metabolism

Substances

Enzyme Inhibitors
Phenylalanine
Carboxypeptidases
Carboxypeptidases A
Thermolysin