[The effect of the parenteral administration of alpha-ketoglutarate on the resistance of rats to ionizing radiation and on their cholinergic systems]

Fiziol Zh. 1999;45(1-2):119-26.
[Article in Ukrainian]

Abstract

We have investigate the effect of sodium ketoglutarate intraperitoneal injection (20 mg/100 g body weight) made 0.5 hour before and 1, 2 and 3 hours after total X-ray treatment (259 mKl/kg) on the survival of rats. Simultaneously we have define changes in cholinesterase-acetylcholine system and content of adrenaline and noradrenaline in liver and pancreas tissues, small intestines mucous and in blood. All the data were taking at 1, 2, 5, 4, 24 and 72 hours after treatment and sodium ketoglutarate injection. We have found that sodium ketoglutarate injection made 0.5 hour before the treatment results in increasing of percentage death rate and injection made 1 and 2 hours after treatment results in increase in survival of rats. The effect of alpha-ketoglutarate injection made 1 hour after treatment in more pronounced. It is accompanied with increase of cholinergic status of organism on the catecholamine deficit background, decrease in the cholinesterase activity and increase of acetylcholine content in tissues of treated organism.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cholinesterases / drug effects
  • Cholinesterases / radiation effects
  • Drug Evaluation, Preclinical
  • Injections, Intraperitoneal
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / enzymology
  • Intestinal Mucosa / radiation effects
  • Ketoglutaric Acids / administration & dosage*
  • Ketoglutaric Acids / pharmacology
  • Liver / drug effects
  • Liver / enzymology
  • Liver / radiation effects
  • Male
  • Pancreas / drug effects
  • Pancreas / enzymology
  • Pancreas / radiation effects
  • Radiation Injuries, Experimental / drug therapy
  • Radiation Injuries, Experimental / enzymology
  • Radiation Injuries, Experimental / prevention & control
  • Radiation Tolerance / drug effects*
  • Radiation-Protective Agents / administration & dosage*
  • Radiation-Protective Agents / pharmacology
  • Rats
  • Receptors, Cholinergic / drug effects*
  • Receptors, Cholinergic / radiation effects*
  • Time Factors
  • Whole-Body Irradiation

Substances

  • Ketoglutaric Acids
  • Radiation-Protective Agents
  • Receptors, Cholinergic
  • Cholinesterases