Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice

Neuroreport. 1999 Feb 5;10(2):289-92. doi: 10.1097/00001756-199902050-00015.

Abstract

To assess the possible modulatory effects of insulin-like growth factor-1 (IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice were injected into the lateral ventricle of the brain with a behaviorally depressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or action of proinflammatory cytokines in the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Brain / physiology*
  • Dose-Response Relationship, Drug
  • Exploratory Behavior / drug effects
  • Injections, Intraventricular
  • Insulin-Like Growth Factor I / administration & dosage*
  • Insulin-Like Growth Factor I / antagonists & inhibitors
  • Insulin-Like Growth Factor I / pharmacology
  • Lipopolysaccharides / pharmacology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects
  • Sexual Behavior, Animal / drug effects
  • Time Factors

Substances

  • Lipopolysaccharides
  • Insulin-Like Growth Factor I