An innate view of human pregnancy

Immunol Today. 1999 Mar;20(3):114-8. doi: 10.1016/s0167-5699(98)01393-0.


Our understanding of the immunology of pregnancy has been dominated by the fetal allograft model and by changes in the maternal-specific immune system. Here, Gavin Sacks and colleagues draw attention to substantial and contrasting changes in the maternal innate system and hypothesize that its function and that of monocytes in particular, has a central role in the maternal-fetal relationship.

MeSH terms

  • Animals
  • Female
  • Humans
  • Immunity, Active / immunology
  • Immunity, Innate
  • Monocytes / metabolism
  • Pre-Eclampsia / immunology
  • Pregnancy / immunology*