Immune cell signaling defects in lupus: activation, anergy and death

Immunol Today. 1999 Mar;20(3):119-24. doi: 10.1016/s0167-5699(98)01395-4.


Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Clonal Anergy / immunology*
  • Humans
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Lymphocytes / immunology*
  • Receptors, Antigen, B-Cell / deficiency
  • Receptors, Antigen, B-Cell / immunology*
  • Receptors, Antigen, T-Cell / deficiency
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology*


  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell