Tissue transglutaminase: apoptosis versus autoimmunity

Immunol Today. 1999 Mar;20(3):130-4. doi: 10.1016/s0167-5699(98)01416-9.


Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the proapoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the proapoptotic enzyme tissue transglutaminase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Apoptosis / physiology*
  • Autoantibodies / analysis
  • Autoimmunity*
  • Cells / enzymology
  • Cells / metabolism
  • Humans
  • Protein Processing, Post-Translational*
  • Transglutaminases / immunology*


  • Autoantibodies
  • Transglutaminases