FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function

Immunol Today. 1999 Mar;20(3):135-40. doi: 10.1016/s0167-5699(98)01432-7.


A novel regulator of the alternative complement pathway with functions similar to that of factor H has been identified in human plasma. The cDNA encoding this factor H-like protein 1 (FHL-1/reconectin) was isolated several years ago. Here, Peter Zipfel and Christine Skerka describe functional analyses revealing that this novel complement regulatory protein forms a molecular link between immune defense and cell adhesion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Catalytic Domain / physiology
  • Cell Adhesion*
  • Chromosomes, Human, Pair 1 / genetics
  • Complement Factor H / genetics
  • Complement Factor H / physiology*
  • Complement Pathway, Alternative*
  • Humans
  • Streptococcus pyogenes / metabolism
  • Streptococcus pyogenes / pathogenicity


  • complement factor H, human
  • Complement Factor H