Regional specialization in the mucosal immune system: what happens in the microcompartments?

Immunol Today. 1999 Mar;20(3):141-51. doi: 10.1016/s0167-5699(98)01413-3.


Mucosal immunity is an important arm of the immune system because it operates in tissues involved in everyday infectious defence as well as in tolerance against innocuous environmental and dietary antigens. Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocytes / immunology*
  • Humans
  • Immunity, Active*
  • Immunity, Mucosal / physiology*
  • Immunoglobulin A / immunology
  • Intestinal Mucosa / immunology


  • Immunoglobulin A