Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human

Trends Genet. 1999 Mar;15(3):98-103. doi: 10.1016/s0168-9525(98)01670-9.


The COP9 signalosome, once defined as a repressor complex of light-activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signaling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signaling pathways and cell-cycle progression. The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological role in animals remains to be determined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Arabidopsis / metabolism
  • COP9 Signalosome Complex
  • Cell Nucleus / metabolism
  • Humans
  • Multiprotein Complexes
  • Peptide Hydrolases
  • Plant Proteins / chemistry
  • Plant Proteins / metabolism*
  • Proteins*
  • Signal Transduction*


  • Multiprotein Complexes
  • Plant Proteins
  • Proteins
  • Peptide Hydrolases
  • COP9 Signalosome Complex