Clostridium Perfringens: Toxinotype and Genotype

Trends Microbiol. 1999 Mar;7(3):104-10. doi: 10.1016/s0966-842x(98)01430-9.


Clostridium perfringens is a ubiquitous pathogen that produces many toxins and hydrolytic enzymes. Because the toxin-encoding genes can be located on extrachromosomal elements or in variable regions of the chromosome, several pathovars have arisen, each of which is involved in a specific disease. Pathovar identification is required for a precise diagnosis of associated pathologies and to define vaccine requirements. For these purposes, toxin genotyping is more reliable than the classical toxinotyping.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Toxins / classification
  • Bacterial Toxins / genetics*
  • Clostridium perfringens / genetics*
  • Genes, Bacterial
  • Genotype
  • Humans
  • Phenotype


  • Bacterial Toxins