Domain organization and oligomerization among H-NS-like nucleoid-associated proteins in bacteria

Trends Microbiol. 1999 Mar;7(3):124-8. doi: 10.1016/s0966-842x(99)01455-9.


The bacterial nucleoid-associated proteins H-NS and StpA can form homomeric or heteromeric complexes, a parallel with protein HU. Thus, functional modulation of H-NS and StpA by one another and by other proteins with appropriate interaction domains is possible. This has implications for bacterial pathogenesis and adaptation to environmental stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Escherichia coli Proteins*
  • Molecular Chaperones*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Bacterial Proteins
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • H-NS protein, bacteria
  • Molecular Chaperones
  • StpA protein, E coli
  • histone-like protein HU, bacteria