Dose response studies: how do we make them conclusive?

Stat Med. 1999 Mar 30;18(6):629-41. doi: 10.1002/(sici)1097-0258(19990330)18:6<629::aid-sim72>;2-y.


In this paper we discuss how to make meaningful use of a dose response study. It is argued that concepts like the minimal effective dose are not clinically meaningful and that the purpose of a dose response study should be to identify the drug potency in relation to a known active control. We also discuss various ways of carrying out the analysis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Review

MeSH terms

  • Dose-Response Relationship, Drug*
  • Drug Evaluation / statistics & numerical data*
  • Drug Evaluation / trends
  • Humans
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmacology / statistics & numerical data*
  • Pharmacology / trends


  • Pharmaceutical Preparations