Suppression of positional errors in biological development

Math Biosci. 1999 Mar 1;156(1-2):271-90. doi: 10.1016/s0025-5564(98)10070-6.

Abstract

Cells in developing embryos behave according to their positions in the organism, and therefore seem to be receiving 'positional information'. A widespread view of the mechanism for this is that each cell responds locally to the concentration level of some extracellular chemical which is distributed in a spatial gradient. For molecules conveying and receiving the positional signal, concentrations are likely to be low enough that, per individual cell, only a few thousand molecules may be involved. Fluctuations to be expected in these numbers (Poisson distribution) could readily lead to errors up to a few percent of embryo length in the reading of position. This is an intolerable level of error for some developmental pattern-forming events. Embryos must have means of suppressing such errors. We maintain that this requires communication between cells, and illustrate this by using the reaction part of two well-known Turing-type reaction-diffusion models as the local gradient reader. We show that switching on diffusion in these models leads to adequate suppression of positional errors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Drosophila / embryology*
  • Embryology*
  • Female
  • Models, Biological*
  • Poisson Distribution