Increase in interleukin-6 and Fibrinogen in Peripheral Blood After Swine Dust Inhalation

Scand J Work Environ Health. 1999 Feb;25(1):39-41. doi: 10.5271/sjweh.381.

Abstract

Objectives: The inhalation of dust from swine confinement buildings causes inflammatory responses in the airways with a rise of interleukin-6 (IL-6). The purpose of this study was to confirm the increase in serum IL-6 after inhalation of swine dust and investigate a possible increase in plasma fibrinogen.

Methods: Eight healthy nonsmoking volunteers inhaled dust for 4 hours inside a swine confinement building. Inhalable dust and endotoxin were sampled. The concentrations of IL-6 and fibrinogen were determined in serum and plasma.

Results: The study showed a clear increase in the concentrations of IL-6 and fibrinogen after exposure.

Conclusions: As fibrinogen is an important risk factor for ischemic heart disease, the increased concentration of fibrinogen among persons exposed to swine dust may increase the risk for this disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Dust / adverse effects*
  • Endotoxins / adverse effects*
  • Female
  • Fibrinogen / metabolism*
  • Humans
  • Inhalation Exposure / adverse effects
  • Interleukin-6 / blood*
  • Linear Models
  • Male
  • Swine*

Substances

  • Dust
  • Endotoxins
  • Interleukin-6
  • Fibrinogen