Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease

J Hum Hypertens. 1999 Mar;13(3):203-8. doi: 10.1038/sj.jhh.1000778.

Abstract

In a randomised, double-blind trial among patients receiving antihypertensive medication, the effects of the oral treatment with coenzyme Q10 (60 mg twice daily) were compared for 8 weeks in 30 (coenzyme Q10: group A) and 29 (B vitamin complex: group B) patients known to have essential hypertension and presenting with coronary artery disease (CAD). After 8 weeks of follow-up, the following indices were reduced in the coenzyme Q10 group: systolic and diastolic blood pressure, fasting and 2-h plasma insulin, glucose, triglycerides, lipid peroxides, malondialdehyde and diene conjugates. The following indices were increased: HDL-cholesterol, vitamins A, C, E and beta-carotene (all changes P<0.05). The only changes in the group taking the B vitamin complex were increases in vitamin C and beta-carotene (P<0.05). These findings indicate that treatment with coenzyme Q10 decreases blood pressure possibly by decreasing oxidative stress and insulin response in patients with known hypertension receiving conventional antihypertensive drugs.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Blood Glucose / metabolism
  • Blood Pressure / drug effects*
  • Coenzymes
  • Coronary Disease / blood
  • Coronary Disease / complications
  • Coronary Disease / drug therapy*
  • Cytoprotection
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / blood
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Insulin / blood
  • Insulin Resistance*
  • Lipid Peroxides / blood
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Oxidative Stress / drug effects
  • Surveys and Questionnaires
  • Treatment Outcome
  • Triglycerides / blood
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use

Substances

  • Antioxidants
  • Blood Glucose
  • Coenzymes
  • Insulin
  • Lipid Peroxides
  • Triglycerides
  • Ubiquinone
  • Malondialdehyde
  • coenzyme Q10