Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors

Science. 1999 Apr 16;284(5413):505-7. doi: 10.1126/science.284.5413.505.

Abstract

In mammals, ocular photoreceptors mediate an acute inhibition of pineal melatonin by light. The effect of rod and cone loss on this response was assessed by combining the rd mutation with a transgenic ablation of cones (cl) to produce mice lacking both photoreceptor classes. Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers. These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Clocks / physiology
  • Circadian Rhythm / physiology*
  • Cryptochromes
  • Darkness
  • Drosophila Proteins*
  • Eye Proteins*
  • Flavoproteins / genetics
  • Flavoproteins / physiology
  • Light Signal Transduction
  • Light*
  • Melatonin / metabolism*
  • Mice
  • Mice, Inbred C3H
  • Mice, Transgenic
  • Photoreceptor Cells, Invertebrate*
  • Photoreceptor Cells, Vertebrate / physiology*
  • Pineal Gland / metabolism*
  • Receptors, G-Protein-Coupled
  • Retina / cytology
  • Retina / physiology*
  • Retinal Ganglion Cells / physiology
  • Retinal Pigments / genetics
  • Retinal Pigments / physiology

Substances

  • Cryptochromes
  • Drosophila Proteins
  • Eye Proteins
  • Flavoproteins
  • Receptors, G-Protein-Coupled
  • Retinal Pigments
  • cry protein, Drosophila
  • Melatonin