Group I mGlu receptor modulation of dopamine release in the rat striatum in vivo

Eur J Pharmacol. 1999 Mar 19;369(2):175-81. doi: 10.1016/s0014-2999(99)00072-2.


The present study investigated the ability of mGlu (metabotropic glutamate) receptor to modulate dopamine release in the striatum of freely moving rats assessed using the microdialysis technique. The group I and II mGlu receptor agonist (1S,3R)-ACPD (1-amino-cyclopentane-1,3-dicarboxylate; 1-3 mM) increased dopamine release (367% of basal levels) which was prevented by the non-selective mGlu receptor antagonist, (+)-MCPG (alpha-methyl-4-carboxyphenylglycine; 10 mM). The group I mGlu receptor agonist, DHPG (3,5-dihydroxyphenylglycine; 0.3-1 mM), also increased dopamine release (maximum increase 229%) which was also antagonised by (+)-MCPG (10 mM). In contrast, the group II mGlu receptor agonist, DCG-IV (2-(2,3-dicarboxycyclopropyl)glycine; 3-50 microM), induced a more modest increase in dopamine release (156% of basal levels). Combined administration of DHPG (1 mM) and DCG-IV (50 microM) maximally increased dopamine release by 252% of basal levels which was antagonised completely by (+)-MCPG (10 mM). Such findings indicate that group I (and possibly group II) mGlu receptors facilitate rat striatal dopamine release in vivo.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Chromatography, High Pressure Liquid
  • Cycloleucine / analogs & derivatives*
  • Cycloleucine / pharmacology
  • Dopamine / metabolism*
  • Drug Interactions
  • Electrochemistry
  • Female
  • Microdialysis
  • Rats
  • Rats, Wistar
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / classification
  • Receptors, Metabotropic Glutamate / physiology*
  • Visual Cortex / drug effects
  • Visual Cortex / metabolism*


  • Receptors, Metabotropic Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Dopamine