Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer

Br J Cancer. 1999 Apr;79(11-12):1935-7. doi: 10.1038/sj.bjc.6690308.


Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated, diffuse and invasive gastric cancers. A recent study of two gastric cancer families has shown that germline mutations in the E-cadherin gene can be causative (Guilford P et al, Nature 1998; 26: 402-405). We have examined the E-cadherin gene for constitutive mutations in a systematic series of 106 gastric cancer patients, 10 with a family history of the disease and 96 sporadic cases. No pathogenic mutations were observed in any of the 106 patients. The results indicate that germline mutations in E-cadherin will not account for more than 3% of gastric cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / etiology
  • Adenocarcinoma / genetics*
  • Cadherins / genetics*
  • Environmental Health*
  • Female
  • Germ-Line Mutation*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / genetics*


  • Cadherins