Serum free insulin-like growth factor-I is dose-dependently decreased by methylprednisolone and related to body weight changes in rats

Growth Horm IGF Res. 1999 Feb;9(1):74-80. doi: 10.1054/ghir.1999.0090.

Abstract

Glucocorticoids usually inhibit growth despite a paradoxical increase in total IGF-I. To investigate the effect of methylprednisolone on free IGF-I, rats were treated with for 3 days (0, 1, 2, 4, and 6 mg/kg per day). A dose-dependent decrease in ultrafiltrated serum free IGF-I was observed, being lowest after 6 mg/kg (P < 0.001 all groups vs controls). Total IGF-I was increased in the groups receiving 2 mg/kg (P < 0.05). Weight change in the 24 h prior to blood sampling was positively correlated with free IGF-I (R = 0.46, P = 0.0002), but not with total IGF-I. Immunoassayable IGFBP-1 was decreased in rats given 4 mg/kg (P = 0.001), whereas there was no change in IGFBP-3 or acid-labile subunit. We propose that in rats the glucocorticoid-induced weight loss may in part be due to suppression of circulating free IGF-I.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Body Weight / physiology*
  • Energy Intake / drug effects
  • Fasting
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / pharmacology
  • Injections, Subcutaneous
  • Insulin-Like Growth Factor Binding Protein 1 / blood
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor I / drug effects
  • Insulin-Like Growth Factor I / metabolism*
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / pharmacology*
  • Rats
  • Rats, Wistar
  • Regression Analysis
  • Ultrafiltration

Substances

  • Blood Glucose
  • Glucocorticoids
  • Insulin-Like Growth Factor Binding Protein 1
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I
  • Methylprednisolone