Pathogenesis of pituitary tumors

Endocrinol Metab Clin North Am. 1999 Mar;28(1):1-12, v. doi: 10.1016/s0889-8529(05)70055-4.


This article focuses on the molecular events associated with pituitary tumorigenesis. An accurate description of the molecular pathogenesis of pituitary adenomas will have an important impact on clinical practice: identification of specific molecular markers of tumor invasiveness and recurrence will allow earlier therapeutic intervention and selection of appropriate follow-up protocols; family screening may become practically feasible; and potent subcellular therapies may be developed for patients with nonfunctioning tumors, in whom nonsurgical therapies are ineffective, and for those with resistant hormone-secreting tumors.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Hypothalamus / physiopathology
  • Mice
  • Mice, Transgenic
  • Mutation
  • Pituitary Neoplasms / etiology*
  • Pituitary Neoplasms / genetics
  • Pituitary Neoplasms / physiopathology