Method for constructing confidently ordered linkage maps

Genet Epidemiol. 1999;16(4):337-43. doi: 10.1002/(SICI)1098-2272(1999)16:4<337::AID-GEPI1>3.0.CO;2-T.


We describe a method for identifying, from a comprehensive genetic map, the most dense framework of confidently ordered markers. The approach uses the number of observed recombination events between each pair of markers, and finds the largest subset of markers for which adjacent loci are separated by at least one recombination. We illustrate the approach using a short region of chromosome 7p.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms*
  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 7 / genetics*
  • Genetic Markers / genetics*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Lod Score
  • Recombination, Genetic / genetics*
  • Software


  • Genetic Markers