Abstract
We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly.
Copyright 1999 Academic Press.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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Cloning, Molecular
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Connectin
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Down-Regulation
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Gene Expression Regulation, Developmental*
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Hindlimb
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Humans
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Mice
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Molecular Sequence Data
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Muscle Fibers, Skeletal / metabolism
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Muscle Proteins / chemistry
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Muscle Proteins / genetics
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Muscle Proteins / metabolism*
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Muscle, Skeletal / innervation
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Muscle, Skeletal / metabolism
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Myocardium / metabolism
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Organ Specificity
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Phenotype
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Phylogeny
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Sarcoplasmic Reticulum / metabolism*
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Sciatic Nerve / surgery
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Sequence Homology, Amino Acid
Substances
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Connectin
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Muscle Proteins
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RNA, Messenger
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TCAP protein, human
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Tcap protein, mouse