Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung

Biochem Biophys Res Commun. 1999 Apr 21;257(3):891-4. doi: 10.1006/bbrc.1999.0562.


Endothelial growth factors have become the target of intense research since the initial discovery of vascular endothelial growth factor (VEGF/VPF). At present, VEGF is established as a major inducer of angiogenesis in normal and pathological conditions. Recently several new members in the VEGF family have been described; VEGF-B/VRF, VEGF-C and VEGF-D. VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. We have here examined the expression pattern of vegf-d mRNA with in situ hybridization in developing and adult mice. This shows a restricted expression pattern, with high levels mainly in lung tissue. The expression in embryonic lung is upregulated prior to birth. Expression of vegf-d in other tissues, as well as in lung tissue of the E14 embryo, was either low or absent. This suggests that VEGF-D may be of special relevance for the vascularization of lung tissue during the last trimester of fetal development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Embryo, Mammalian / metabolism
  • Embryonic and Fetal Development
  • Endothelial Growth Factors / genetics*
  • Female
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Kidney / metabolism
  • Lung / embryology*
  • Lung / growth & development
  • Lung / metabolism
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oligonucleotides / genetics
  • Organ Specificity
  • RNA, Messenger / metabolism
  • Seminiferous Tubules / metabolism
  • Spine / embryology
  • Spine / metabolism
  • Thymus Gland / metabolism
  • Up-Regulation*
  • Vascular Endothelial Growth Factor D


  • Endothelial Growth Factors
  • Oligonucleotides
  • RNA, Messenger
  • Vascular Endothelial Growth Factor D