Developmental neurobiology: Alternative ends for a familiar story?

Curr Biol. 1999 Apr 8;9(7):R251-3. doi: 10.1016/s0960-9822(99)80156-0.

Abstract

Somatic DNA recombination is essential for production of functional antigen receptor genes of T and B lymphocytes, but it is thought to be unique to the immune system. Recent studies have now shown that recombination-related genes are also necessary for normal neuronal development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System / cytology
  • Central Nervous System / embryology*
  • Central Nervous System / metabolism
  • DNA Ligase ATP
  • DNA Ligases / genetics
  • DNA-Binding Proteins / genetics
  • Gene Expression Regulation, Developmental
  • Gene Rearrangement / genetics
  • Homeodomain Proteins / genetics
  • Immune System / cytology
  • Immune System / embryology
  • Immune System / metabolism
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / metabolism
  • Neurons / cytology
  • Neurons / metabolism

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • XRCC4 protein, human
  • RAG-1 protein
  • DNA Ligases
  • DNA Ligase ATP