Regulation of tyrosine kinase cascades by G-protein-coupled receptors

Curr Opin Cell Biol. 1999 Apr;11(2):177-83. doi: 10.1016/s0955-0674(99)80023-4.


Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arrestins / physiology
  • Cell Adhesion
  • Clathrin / physiology
  • Endocytosis
  • Enzyme Activation
  • GTP-Binding Proteins / physiology*
  • Models, Biological
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / physiology*
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology*
  • beta-Arrestins
  • src-Family Kinases / physiology


  • Arrestins
  • Clathrin
  • Receptors, Cell Surface
  • beta-Arrestins
  • Protein-Tyrosine Kinases
  • src-Family Kinases
  • GTP-Binding Proteins