Epidermal growth factor receptors: critical mediators of multiple receptor pathways

Curr Opin Cell Biol. 1999 Apr;11(2):184-9. doi: 10.1016/s0955-0674(99)80024-6.


Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Dimerization
  • Enzyme Activation
  • Epidermal Growth Factor / physiology*
  • ErbB Receptors / chemistry
  • ErbB Receptors / physiology*
  • Models, Biological
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein Tyrosine Phosphatases / physiology
  • Signal Transduction / physiology*


  • Epidermal Growth Factor
  • ErbB Receptors
  • Protein Tyrosine Phosphatases