Regulating the Onset of Mitosis

Curr Opin Cell Biol. 1999 Apr;11(2):267-73. doi: 10.1016/s0955-0674(99)80036-2.

Abstract

In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • CDC2 Protein Kinase / physiology*
  • Cell Compartmentation
  • Cell Cycle / physiology
  • Cyclin B / physiology*
  • DNA Damage
  • Drosophila Proteins*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Fungal Proteins / physiology
  • Fungi / cytology
  • Fungi / physiology
  • G2 Phase
  • Humans
  • Maturation-Promoting Factor / physiology*
  • Mitosis / physiology*
  • Models, Biological
  • Phosphorylation
  • Protein Isoforms / physiology
  • Protein Processing, Post-Translational / physiology
  • Protein-Serine-Threonine Kinases / physiology
  • Protein-Tyrosine Kinases / physiology
  • Spindle Apparatus / physiology
  • Vertebrates / physiology
  • Xenopus laevis / physiology

Substances

  • CycB protein, Drosophila
  • Cyclin B
  • Drosophila Proteins
  • Fungal Proteins
  • Protein Isoforms
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • CDC2 Protein Kinase
  • Maturation-Promoting Factor