Mycobacterium tuberculosis phagosome

Mol Microbiol. 1999 Mar;31(6):1603-9. doi: 10.1046/j.1365-2958.1999.01279.x.

Abstract

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Carrier Proteins / physiology
  • Cation Transport Proteins*
  • Cells, Cultured
  • Cytokines / physiology
  • GTP-Binding Proteins / metabolism
  • Membrane Proteins / physiology
  • Microscopy, Confocal
  • Models, Biological
  • Mycobacterium bovis / metabolism
  • Mycobacterium tuberculosis / physiology*
  • Phagocytosis / physiology
  • Phagosomes / metabolism*
  • rab GTP-Binding Proteins*
  • rab5 GTP-Binding Proteins

Substances

  • Carrier Proteins
  • Cation Transport Proteins
  • Cytokines
  • Membrane Proteins
  • natural resistance-associated macrophage protein 1
  • rab7 protein
  • GTP-Binding Proteins
  • rab GTP-Binding Proteins
  • rab5 GTP-Binding Proteins