Venous thrombosis: a multicausal disease

Lancet. 1999 Apr 3;353(9159):1167-73. doi: 10.1016/s0140-6736(98)10266-0.


The risk factors for venous thrombosis differ from those for arterial vascular disease. During the past 5 years, knowledge about the aetiology of venous thrombosis has advanced with the discovery of several factors that contribute to the incidence of thrombosis, particularly the role of coagulation abnormalities. These abnormalities are common in the general population and therefore will be present simultaneously in some individuals. The resultant gene-gene and gene-environment interactions between risk factors are the key to the understanding of why a certain person develops thrombosis at a specific point in time.

Publication types

  • Review

MeSH terms

  • Contraceptives, Oral / adverse effects
  • Environmental Exposure / adverse effects
  • Factor V / genetics
  • Female
  • Humans
  • Immobilization / adverse effects
  • Models, Statistical
  • Neoplasms / complications
  • Pregnancy
  • Pregnancy Complications, Hematologic / etiology
  • Prevalence
  • Protein C Deficiency / complications
  • Protein S Deficiency / complications
  • Risk Factors
  • Survival Analysis
  • Venous Thrombosis / epidemiology
  • Venous Thrombosis / etiology*
  • Venous Thrombosis / genetics
  • Wounds and Injuries / complications


  • Contraceptives, Oral
  • factor V Leiden
  • Factor V