Prostaglandin in the saliva of the cattle tick Boophilus microplus

Aust J Exp Biol Med Sci. 1976 Oct;54(5):475-86. doi: 10.1038/icb.1976.48.

Abstract

Previous studies of saliva from engorged female cattle ticks revealed a component which induced contration of some isolated smooth muscles. Fractionation and further characterisation have shown that this substance is of the "slow-reacting" type, but that it is neither a bradykinin nor slow-reacting substance of anaphylaxis. The substance is deactivated by incubation with 15-hydroxprostaglandin dehydrogenase and its pharmacological properties also support its classification as a prostaglandin. A second pharmacologically-active component has now been found in the saliva but has not yet been characterised.

MeSH terms

  • Animals
  • Biological Assay
  • Chromatography, Gel
  • Female
  • Ileum / drug effects
  • Muscle, Smooth / drug effects
  • Pilocarpine / analysis
  • Prostaglandins / analysis*
  • Saliva / analysis*
  • Stomach / drug effects
  • Ticks / analysis*
  • Uterus / drug effects

Substances

  • Prostaglandins
  • Pilocarpine