Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid

J Pathol. 1998 Nov;186(3):287-91. doi: 10.1002/(SICI)1096-9896(199811)186:3<287::AID-PATH175>3.0.CO;2-X.


Met protein encoded by MET oncogene is the high affinity receptor for hepatocyte growth factor (HGF)/scatter factor (SF). HGF/SF has to be cleaved in its heterodimeric form by the urokinase-type plasminogen activator (uPA) to become active as a ligand for Met receptor. The expression of Met protein and of the high affinity receptor for uPA (uPA-R) was investigated in 39 samples of papillary carcinoma using immunohistochemistry. Reactivity for Met protein was present in 33 of 34 tumours, mostly with a diffuse pattern of staining. Reactivity for uPA-R was present in 78 per cent of papillary tumours and exhibited a pattern of staining similar to that of Met protein. Staining for uPA-R was present in 23 of 25 cases (92 per cent) of papillary carcinoma with prominent sclerosis, and in only 1 of 7 cases (14 per cent) without sclerosis. Peritumoural normal thyroid, follicular adenomas, and follicular carcinomas were negative for Met protein and for uPA-R. Hyperfunctioning tall thyroid cells showed weak membrane reactivity for uPA-R and for Met protein. The findings of immunohistochemistry were confirmed at the mRNA level using in situ hybridization, since the signal for uPA-R and Met RNAs was detected in most tumour cells of five cases of papillary carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Papillary / chemistry*
  • Carcinoma, Papillary / secondary*
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Plasminogen Activators / analysis*
  • Proto-Oncogene Proteins c-met / analysis*
  • Receptors, Cell Surface / analysis*
  • Receptors, Urokinase Plasminogen Activator
  • Thyroid Neoplasms / chemistry*


  • PLAUR protein, human
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • Proto-Oncogene Proteins c-met
  • Plasminogen Activators