Diet and risk of cancer of the upper aerodigestive tract--II. Nutrients

Oral Oncol. 1999 Jan;35(1):22-6. doi: 10.1016/s1368-8375(98)00061-x.

Abstract

In order to examine the risks of cancer of the upper aerodigestive tract (UADC) associated with nutrient intake, a case-control study was conducted in Uruguay in the period of January 1996-December 1997. All patients afflicted with cancer of the oral cavity, pharynx, larynx, and esophagus, were included in the study. Cases were frequency-matched with hospitalized patients on age, sex, residence, and urban/rural status. A strong positive association with protein intake was observed (OR 2.5, 95% CI 1.5-4.4), whereas antioxidants were associated with an inverse association (OR for vitamin C 0.5, 95% CI 0.3-0.8). Non-nutritive substances, like flavonoids displayed a marked reduction in risk of 70%. Possible mechanisms for these findings are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Diet / adverse effects*
  • Dietary Fats / adverse effects
  • Dietary Fiber
  • Dietary Proteins / adverse effects
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / etiology*
  • Female
  • Humans
  • Laryngeal Neoplasms / epidemiology
  • Laryngeal Neoplasms / etiology*
  • Male
  • Middle Aged
  • Minerals
  • Mouth Neoplasms / epidemiology
  • Mouth Neoplasms / etiology*
  • Pharyngeal Neoplasms / epidemiology
  • Pharyngeal Neoplasms / etiology*
  • Risk Factors
  • Uruguay / epidemiology
  • Vitamins / administration & dosage

Substances

  • Dietary Fats
  • Dietary Fiber
  • Dietary Proteins
  • Minerals
  • Vitamins