IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma

Cancer Lett. 1999 Feb 8;136(1):1-9. doi: 10.1016/s0304-3835(98)00281-x.


We investigated the expression of IL-10 in oral and oropharyngeal squamous cell carcinoma (SCC) specimens by an immunohistochemical technique. Of 58 SCC, 13 (22%) and 35 (60%) cases showed intense and moderate positive staining of IL-10, respectively. There was no association between the staining of IL-10 and clinicopathological features. However, the patients with intense staining of IL-10 had a significantly lower overall survival rate than those with moderate or negative staining of IL-10 (P = 0.019). In addition, the patients with intense staining of IL-10 had the highest score of platelet-derived endothelial cell growth factor (PD-ECGF), which is established as a poor prognostic indicator (P = 0.0105). These results suggested that IL-10 contributes to the clinical outcome of oral and oropharyngeal SCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / chemistry*
  • Carcinoma, Squamous Cell / pathology
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunoenzyme Techniques
  • Interleukin-10 / analysis*
  • Lymphatic Metastasis
  • Male
  • Mouth Neoplasms / chemistry*
  • Mouth Neoplasms / pathology
  • Oropharyngeal Neoplasms / chemistry*
  • Oropharyngeal Neoplasms / pathology
  • Prognosis
  • Proportional Hazards Models
  • Risk
  • Risk Factors
  • Survival Analysis
  • Thymidine Phosphorylase / analysis*


  • Interleukin-10
  • Thymidine Phosphorylase