Cisplatin and hypomagnesemia

Cancer Treat Rev. 1999 Feb;25(1):47-58. doi: 10.1053/ctrv.1999.0097.


Hypomagnesemia is a well known side-effect in patients receiving cisplatin-containing chemotherapy. Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle as well as the distal tubule. Since the magnesium reabsorption process still remains to be fully characterized, the effect by cisplatin on this process remains uncertain. Hypomagnesemia is a frequent complication to chemotherapy with cisplatin affecting up to 90% of patients if no corrective measures are initiated. The clinical importance of this hypomagnesemia remains uncertain. Possible symptoms of hypomagnesemia can be impossible to distinguish from symptoms related to the underlying disease or the treatment with chemotherapy. Existing studies on how to supplement magnesium during treatment with cisplatin have focused mainly on the effect on serum magnesium values and erythrocyte magnesium concentrations but both parameters are poor indicators of body magnesium stores. As long as the relationship between hypomagnesemia and possible complications thereof remains poorly elucidated, it seems reasonable to try to avoid hypomagnesemia. The best results seem to be provided by adding magnesium to the pre- and posthydration fluids.

Publication types

  • Review

MeSH terms

  • Absorption
  • Animals
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Fluid Therapy / adverse effects
  • Humans
  • Hypokalemia / etiology
  • Kidney Tubular Necrosis, Acute / chemically induced*
  • Kidney Tubular Necrosis, Acute / complications
  • Kidney Tubules, Distal / metabolism
  • Loop of Henle / metabolism
  • Magnesium / pharmacokinetics
  • Magnesium / therapeutic use
  • Magnesium Deficiency / blood
  • Magnesium Deficiency / diagnosis
  • Magnesium Deficiency / drug therapy
  • Magnesium Deficiency / etiology*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Neoplasms, Experimental / complications
  • Neoplasms, Experimental / drug therapy
  • Randomized Controlled Trials as Topic
  • Rats


  • Antineoplastic Agents
  • Magnesium
  • Cisplatin