Potentiation by taurine of the inotropic effect of ouabain and the content of intracellular Ca++ and taurine in the heart

Experientia. 1976 Dec 15;32(12):1559-61. doi: 10.1007/BF01924452.

Abstract

Under certain conditions, taurine (3.0mM) potentiated cardiac contractile response to ouabain in the normal medium. The potentiation by taurine was also observed in the low K+ medium, in which the positive inotropic effect of ouabain increased. The potentiation as seen in both media was, at least in part, due to the increase by taurine of Ca++ content in the heart. Taurine in the heart was not directly related to this potentiation.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Drug Synergism
  • Guinea Pigs
  • Heart / drug effects*
  • Heart / physiology
  • Male
  • Myocardial Contraction / drug effects
  • Myocardium / metabolism
  • Ouabain / pharmacology*
  • Potassium / pharmacology
  • Taurine / metabolism
  • Taurine / pharmacology*

Substances

  • Taurine
  • Ouabain
  • Potassium
  • Calcium