Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair

Biochimie. Jan-Feb 1999;81(1-2):127-37. doi: 10.1016/s0300-9084(99)80045-5.

Abstract

In recent years, mouse models have been generated to study the syndromes associated with a defect in nucleotide excision repair (NER). Thus, via conventional knockout gene targeting or by mimicking patient-specific alleles, mouse models for xeroderma pigmentosum (XP), Cockayne syndrome (CS) and photosensitive trichothiodystrophy (TTD) have been obtained. The generation of this series of mouse mutants allows in vivo investigation of some intriguing questions that have puzzled the field, such as the paradoxical absence of cancer development in TTD and CS despite their NER deficiencies, and the role of the ERCC1 gene in mitotic recombination and cross-link repair. Other interesting issues include the pathophysiology of the non-NER related clinical symptoms in TTD and CS patients and the proposed involvement of NER and transcription in the process of aging. This review will focus on data obtained thus far and discuss further utilization of the mouse mutants for unraveling some of the fascinating and medically relevant aspects associated with defects in NER and related processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics*
  • Animals
  • DNA Repair*
  • Disease Models, Animal
  • Humans
  • Mice
  • Mutagens / toxicity
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / genetics*
  • Neoplasms, Radiation-Induced / genetics
  • Ultraviolet Rays

Substances

  • Mutagens