Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide

Ann Intern Med. 1999 Apr 20;130(8):658-60. doi: 10.7326/0003-4819-130-8-199904200-00012.


Background: Chronic hypercalciuria can contribute to osteoporosis, particularly in men.

Objective: To ascertain the effects of resolution of hypercalciuria on bone mineral density.

Design: Case series.

Setting: Referral service for metabolic bone disease in a tertiary-care teaching hospital.

Patients: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.

Intervention: Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months.

Measurements: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.

Results: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.

Conclusions: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Bone Density / drug effects*
  • Calcium / urine*
  • Chronic Disease
  • Creatinine / urine
  • Diuretics
  • Humans
  • Hydrochlorothiazide / therapeutic use*
  • Middle Aged
  • Osteoporosis / drug therapy*
  • Osteoporosis / physiopathology
  • Osteoporosis / urine*
  • Sodium Chloride Symporter Inhibitors / therapeutic use*


  • Diuretics
  • Sodium Chloride Symporter Inhibitors
  • Hydrochlorothiazide
  • Creatinine
  • Calcium