Efficacy of two dose measles vaccination in a community setting

Indian Pediatr. 1998 Aug;35(8):723-5.


Objective: To compare the efficacy of two dose and single dose measles vaccination in a community setting.

Design: Two community ICDS blocks with populations of 8990 and 8550 children below 12 years of age were selected. Block A had 1560 children between 9 mo to 1 year of age and Block B had 1380 children between the age of 9 mo to 1 year.

Methods: All eligible children between 9 mo to 1 year of age were given measles vaccination in October 1994. Only the children in Group A were given a second dose of measles (as MMR) in April 1995; six months after the first dose. A survey was undertaken from January 1996 to April 1996 to clinically evaluate the number of cases of measles in both these blocks.

Results: In Block A 3 children developed measles, whereas in Block B, there were 16 cases of measles (p < 0.01). All other parameters in both groups, e.g., cold chain maintenance were similar.

Conclusion: This study supports the superiority of two dose measles vaccination given at an interval of 6 months over a single dose measles in a community setting.

Publication types

  • Comparative Study

MeSH terms

  • Case-Control Studies
  • Humans
  • Immunization Schedule*
  • Immunization, Secondary*
  • Incidence
  • Infant
  • Measles / prevention & control
  • Measles Vaccine / administration & dosage*
  • Measles-Mumps-Rubella Vaccine
  • Mumps Vaccine / administration & dosage
  • Rubella Vaccine / administration & dosage
  • Vaccination*
  • Vaccines, Combined / administration & dosage


  • Measles Vaccine
  • Measles-Mumps-Rubella Vaccine
  • Mumps Vaccine
  • Rubella Vaccine
  • Vaccines, Combined