Translation initiation factor 4E

Int J Biochem Cell Biol. 1999 Jan;31(1):31-5. doi: 10.1016/s1357-2725(98)00129-0.


Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Eukaryotic Initiation Factor-4E
  • Humans
  • Molecular Sequence Data
  • Peptide Initiation Factors / chemistry*
  • Peptide Initiation Factors / genetics
  • Peptide Initiation Factors / metabolism*
  • Phosphorylation
  • RNA, Ribosomal / genetics
  • RNA, Ribosomal / metabolism
  • Sequence Homology, Amino Acid


  • Eukaryotic Initiation Factor-4E
  • Peptide Initiation Factors
  • RNA, Ribosomal