Hepatocellular carcinoma

Lancet. 1999 Apr 10;353(9160):1253-7. doi: 10.1016/S0140-6736(98)09148-X.


Hepatocellular carcinoma (HCC) for most patients is a terminal complication of chronic inflammatory and fibrotic liver disease. With regrettably few exceptions, treatment is largely palliative, and long-term survival is rare. However, the major causes of HCC worldwide are known and preventable. Hepatitis B and C exist only in man; the viruses have no known non-human reservoirs. Transmission of the viruses can be interrupted by vaccination against hepatitis B virus infection and improvements in medical techniques for hepatitis C, for which no vaccine has yet been developed.

Publication types

  • Review

MeSH terms

  • Adult
  • Carcinoma, Hepatocellular* / epidemiology
  • Carcinoma, Hepatocellular* / etiology
  • Carcinoma, Hepatocellular* / pathology
  • Carcinoma, Hepatocellular* / therapy
  • Child
  • Hepatitis B / complications*
  • Hepatitis C / complications*
  • Humans
  • Liver Neoplasms* / epidemiology
  • Liver Neoplasms* / etiology
  • Liver Neoplasms* / pathology
  • Liver Neoplasms* / therapy
  • Liver Transplantation