Lavender oil inhibits immediate-type allergic reaction in mice and rats

J Pharm Pharmacol. 1999 Feb;51(2):221-6. doi: 10.1211/0022357991772178.

Abstract

We studied the effects of lavender oil on mast cell-mediated immediate-type allergic reactions in mice and rats. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 in mice by both topical and intradermal application. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) also inhibited concentration-dependently the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, lavender oil (1:1000, 1:100, 1:10, 1:0) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-alpha secretion from peritoneal mast cells. These results indicate that lavender oil inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in-vivo and in-vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaphylaxis / etiology
  • Anaphylaxis / prevention & control
  • Animals
  • Dinitrobenzenes / immunology
  • Dose-Response Relationship, Drug
  • Female
  • Histamine Release / drug effects
  • Hypersensitivity, Immediate / chemically induced
  • Hypersensitivity, Immediate / prevention & control*
  • Immunoglobulin E / adverse effects
  • Male
  • Mast Cells / drug effects
  • Mast Cells / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Oils, Volatile / pharmacology
  • Oils, Volatile / therapeutic use*
  • Peritoneum / cytology
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Oils*
  • Plants, Medicinal / chemistry
  • Rats
  • Rats, Wistar
  • Skin Diseases / etiology
  • Skin Diseases / prevention & control
  • Tumor Necrosis Factor-alpha / drug effects
  • Tumor Necrosis Factor-alpha / metabolism
  • p-Methoxy-N-methylphenethylamine / adverse effects

Substances

  • Dinitrobenzenes
  • Oils, Volatile
  • Plant Extracts
  • Plant Oils
  • Tumor Necrosis Factor-alpha
  • Immunoglobulin E
  • p-Methoxy-N-methylphenethylamine
  • lavender oil