Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?

Histopathology. 1999 Mar;34(3):266-70. doi: 10.1046/j.1365-2559.1999.00662.x.


Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B-cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.

MeSH terms

  • Cyclin D1 / analysis*
  • Humans
  • Immunohistochemistry
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Reproducibility of Results
  • Staining and Labeling


  • Cyclin D1