Angiopoietin-1 is an apoptosis survival factor for endothelial cells

FEBS Lett. 1999 Apr 9;448(2-3):249-53. doi: 10.1016/s0014-5793(99)00378-6.


We examined the effect of angiopoietin-1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5-1000 ng/ml) dose-dependently inhibited apoptosis under a serum-deprived state. A significant apoptotic inhibition occurred with as low as 50 ng/ml. Two hundred ng/ml of Ang1 inhibited to approximately 50% of the control apoptotic rates for 96 h. Furthermore, an augmented antiapoptotic effect of Ang1 by the addition of 20 ng/ml vascular endothelial growth factor was observed. This Ang1-induced strong antiapoptotic effect in endothelial cells is a novel and intriguing finding and could be an additional description of Ang1-induced direct biological function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiopoietin-1
  • Apoptosis*
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Endothelial Growth Factors / metabolism*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism*
  • Humans
  • Lymphokines / metabolism*
  • Membrane Glycoproteins / metabolism*
  • Recombinant Proteins
  • Time Factors
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • ANGPT1 protein, human
  • Angiopoietin-1
  • Endothelial Growth Factors
  • Lymphokines
  • Membrane Glycoproteins
  • Recombinant Proteins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors