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, 448 (2-3), 292-6

The Induction of GSH Synthesis by Nanomolar Concentrations of NO in Endothelial Cells: A Role for Gamma-Glutamylcysteine Synthetase and Gamma-Glutamyl Transpeptidase

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The Induction of GSH Synthesis by Nanomolar Concentrations of NO in Endothelial Cells: A Role for Gamma-Glutamylcysteine Synthetase and Gamma-Glutamyl Transpeptidase

D Moellering et al. FEBS Lett.

Abstract

Nitric oxide protects cells from oxidative stress through a number of direct scavenging reactions with free radicals but the effects of nitric oxide on the regulation of antioxidant enzymes are only now emerging. Using bovine aortic endothelial cells as a model, we show that nitric oxide, at physiological rates of production (1-3 nM/s), is capable of inducing the synthesis of glutathione through a mechanism involving gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase. This novel nitric oxide signalling pathway is cGMP-independent and we hypothesize that it makes an important contribution to the anti-atherosclerotic and antioxidant properties of nitric oxide.

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