[Neuro-meningeal location of Richter syndrome]

Rev Med Interne. 1999 Jan;20(1):64-7. doi: 10.1016/s0248-8663(99)83011-2.
[Article in French]


Introduction: The authors report a case of neurologic manifestations revealing Richter's syndrome in chronic lymphocytic leukemia.

Exegesis: Cranial nerve palsies were the initial manifestation of the disease. Computed tomography and magnetic resonance imaging were normal. Cerebrospinal fluid analysis with alkaline phosphatase-antialkaline phosphatase revealed the existence of a large-cell lymphoma.

Conclusions: Clinical aspects of this unusual localization of Richter's syndrome are reviewed.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Abducens Nerve / pathology
  • Alkaline Phosphatase / cerebrospinal fluid
  • Cranial Nerve Neoplasms / cerebrospinal fluid
  • Cranial Nerve Neoplasms / pathology*
  • Female
  • Hemiplegia / pathology
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Lymphoma, Large B-Cell, Diffuse / cerebrospinal fluid
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Paralysis / pathology
  • Spinal Cord Neoplasms / cerebrospinal fluid
  • Spinal Cord Neoplasms / pathology*
  • Syndrome


  • Alkaline Phosphatase