Increased salivary interleukin-6 levels in patients with primary Sjögren's syndrome

Rheumatol Int. 1999;18(4):125-7. doi: 10.1007/s002960050070.


This study's purpose was to evaluate salivary interleukin-6 (IL-6) levels in patients with primary Sjögren's syndrome (SS). Salivary and serum IL-6 concentrations were evaluated by ELISA in 36 patients with SS and compared with 19 patients complaining of dry mouth and with normal controls. Salivary IL-6 levels were significantly elevated (P < 0.01) in the 36 patients with SS as compared to the 19 patients with dry mouth (200.5 +/- 43.6 and 12.6 +/- 6.8 pg/ml, respectively). No significant differences were noted in the serum IL-6 levels between these two groups (105.8 +/- 17.1 and 84.8 +/- 17.1 pg/ml, respectively). Both salivary and serum IL-6 levels in the normal controls were below the level of detection of the assay. Positive correlation (r = 0.8613, P < 0.0001) was found between salivary IL-6 levels and the focus score of labial biopsies in SS patients. Elevated salivary IL-6 levels appear to be a consequence of local production and may reflect the component of salivary gland inflammation in SS.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / analysis
  • Biopsy, Needle
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-6 / analysis*
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Reference Values
  • Saliva / chemistry*
  • Sensitivity and Specificity
  • Sjogren's Syndrome / pathology
  • Sjogren's Syndrome / physiopathology*


  • Biomarkers
  • Interleukin-6