Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia

Leuk Lymphoma. 1999 Apr;33(3-4):385-8. doi: 10.3109/10428199909058440.


Bone marrow necrosis (BMN) is a rare pathologic entity associated with a wide variety of diseases. We describe a patient with chronic myeloid leukemia on interferon treatment, who developed BMN with symptoms and signs masquerading as interferon toxicity. This is followed by a literature review of BMN in CML.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow / pathology*
  • Diagnosis, Differential
  • Humans
  • Hydroxyurea / therapeutic use
  • Interferon alpha-2
  • Interferon-alpha / adverse effects
  • Interferon-alpha / therapeutic use*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
  • Male
  • Necrosis
  • Recombinant Proteins


  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Hydroxyurea